Applications

A full battery of base, sugar and internucleotide modifications is available for aptamer development.

Glen Research offers a wide selection of fluorophores and fluorescence quenchers, which can be added during oligonucleotide synthesis at the 5′- or 3’-terminus or within the sequence

A wide range of phosphoramidites and supports is available for research in the design of non-fluorescent probes.

Glen Research offers products for research in DNA crosslinking and ligation.

A variety of products is available for studies in DNA damage and repair.

A variety of products is available for use in the study of duplex stability modification.

A full line of products is available for research in DNA epigentics, one of the fastest growing fields in biology and cancer research is epigenetics.

Cytosine-5-methyltransferases are found in everything from archaebacteria to mammals and when the regulation of cytosine-5-methyltransferases goes awry, cancer can result. Glen Research offers products to aid in the study in the inhibition of DNA methyltransferases.

Glen Research offers a variety of products for the in situ synthesis of DNA analogs.

Glen Research offers a variety of products for use in mutagenesis research.

Products are available for research in non-cononical structures such as G-quadruplexes, triplex forming oligos, hairpins and cruciforms, and i-Motif structures.

A wide range of products for PCR and sequencing applications is available.

Photo-control, the use of ultraviolet or visible light to control a reaction, has a number of advantages over other external stimuli.

The fluorescence of a nucleoside base is highly dependent on the environment of the base and the measurement of its fluorescence is a powerful and sensitive tool for the analysis of DNA and RNA structure.

A wide range of phosphoramidites and supports is available for specialized DNA and RNA synthesis.

A wide variety of modified DNA bases are available that may be used to investigate the effect on the activity of an oligonucleotide when key structural elements are changed.

Brominated and iodinated nucleosides are used in X-ray crystallography studies of oligonucleotide structure.  They are also photolabile and are used for cross-linking studies to probe the structure of protein-DNA complexes.  Antibodies exist to Br-dU and oligonucleotides containing Br-dU can be used as probes. 

A wide variety of modified DNA bases may be used to investigate the effect on the activity of an oligonucleotide when key structural elements are changed. Glen Research offers a wide range of products for research in structural studies.